Returning Candidate?

Pathology Associate III/Sr. Pathology Associate

Pathology Associate III/Sr. Pathology Associate

Job Location 
US-CA-South San Francisco
Regular Full-Time

More information about this job


MacroGenics is a leader in the discovery and development of innovative medicines that utilize our next generation antibody-based technologies.  Our team of 300+ dedicated individuals is advancing a pipeline of product candidates to treat patients with cancer as well as various autoimmune disorders and infectious diseases.  Our products and platforms have attracted multiple partnerships with leading pharmaceutical companies around the globe.


The Company considers its employees to be its most valuable asset and we are committed to providing opportunities for individuals to learn and grow as a means to further their professional development. MacroGenics' corporate culture promotes an atmosphere of innovation, open communication and teamwork where employees can see firsthand how they contribute to the success of the organization.

Summary of Position

The position is responsible for developing pathology-related assays that supports drug discovery and development of MacroGenics’ pipeline of preclinical and clinical programs.  This individual will interact with multiple cross functional project teams, and provide pathology support for target discovery, drug candidate selection, therapeutic modelling, toxicology studies, biomarker development and prevalence studies in tissue micro-array samples. Additionally, the pathology data may be used to support IND filings. This individual will serve as a team player in making effective recommendations for pathology study in supporting projects across our preclinical and clinical pipeline.


Responsibilities and Job Duties:

  • Provide pathology support to research and development project teams and ensure the highest level of data quality and meet project timelines. 
  • Evaluate novel targets and pathway biomarkers in human disease samples, normal tissues and cell-array by immunohistochemistry (chromogen and florescence), in situ hybridization and IHC multiplexing methods.
  • Support preclinical modeling by performing H&E, IHC and ISH studies.
  • Evaluate cell -array stained slides independently to support pipeline mAb characterization.
  • Learn about and implement novel technologies and /or methodologies to support preclinical and clinical stage programs including but not limited to quantitative IHC imaging software algorithms.
  • Maintain detailed written lab records, complete image processing analysis, generate power point slides of stained tissue images and transcribe the pathologists’ findings to ensure high quality of data provided to the project teams. 
  • Collect pathology/IHC data in support of report writing for IND filings.
  • Work with vendors and coordinate with Laboratory Manager to properly maintain histology equipment in good working order.
  • Maintain tissue inventory, and assist with managing tissue bank database as necessary.


Education & Experience


Pathology Associate III:

  • Bachelor’s degree in biology/life sciences with a minimum of five years of histology lab or research experience;


  • Master's degree in biology/life sciences with a minimum of three years of histology lab or research experience.
  • 2 years working experience in histology lab is required.

Sr. Pathology Associate:

  • Bachelor’s degree in biology/life sciences with a minimum of eight years of histology lab or research experience; 


  • Master degree in biology/life sciences with a minimum of five years of histology lab or research experience.
  • 2 years working experience in histology lab is required.


Knowledge, Skills and Abilities


  • Routine histology skills are necessary
  • Knowledge with VIP processing machine, Dako autostainers and Ventana Discovery Ultra platform
  • IHC, ISH, and cell culture, especially fluorescence techniques
  • Working knowledge of florescence microscopy, image scanner and image analysis software 
  • Knowledge of picture editor software and tools
  • Excellent computer skills including MS Word, Excel and PowerPoint
  • Good record keeping, organizational and technical writing skills
  • Ability to work effectively with others on a collaborative team
  • Most importantly, open to learning new techniques
  • Required to be on call for monitoring tissue bank freezers after hours, may occasionally be required work after hours to process tissues.


Supervisory Responsibilities



Preferred Qualifications/experience

  • ASCP Board HT certification 
  • Cell immune assay experience



MacroGenics is proud to be an equal opportunity employer. Employment selection and related decisions are made without regard to race, color, national origin, sex, gender identity, sexual orientation, religion, age, disability, protected veteran status, or any other characteristic protected by federal, state or local law. We are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the employment process, please email or call (301) 354-3566 and/or 711 for TTD/TTY service.

Equal Opportunity Employer/Veterans/Disabled


For more information about our commitment to equal employment opportunity, please click here.